Cigarette Smoke Extract Inhibits Platelet Aggregation by Suppressing Cyclooxygenase Activity
نویسندگان
چکیده
1Department of Pharmacology, Asahikawa Medical University, Asahikawa, Japan 2Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo, Japan 3Department of Pharmacology, Kitasato University, Sagamihara, Japan 4Department of Cellular Pharmacology, Hokkaido University Graduate School of Medicine, Sapporo, Japan 5Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
منابع مشابه
Piperine Inhibits the Activities of Platelet Cytosolic Phospholipase A2 and Thromboxane A2 Synthase without Affecting Cyclooxygenase-1 Activity: Different Mechanisms of Action Are Involved in the Inhibition of Platelet Aggregation and Macrophage Inflammatory Response
PURPOSE Piperine, a major alkaloid of black pepper (Piper nigrum) and long pepper (Piper longum), was shown to have anti-inflammatory activity through the suppression of cyclooxygenase (COX)-2 gene expression and enzyme activity. It is also reported to exhibit anti-platelet activity, but the mechanism underlying this action remains unknown. In this study, we investigated a putative anti-platele...
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